Full analysis

Forest plot

Funnel plot

Egger’s test

## [1] "No replication of infants across vaccines or significant vaccine effect, therefore combined test performed"
## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.9341, p = 0.0531

Meta-analysis output

## 
## Random-Effects Model (k = 5; tau^2 estimator: REML)
## 
##   logLik  deviance       AIC       BIC      AICc  
##   0.8350   -1.6700    2.3300    1.1026   14.3300  
## 
## tau^2 (estimated amount of total heterogeneity): 0.0120 (SE = 0.0265)
## tau (square root of estimated tau^2 value):      0.1094
## I^2 (total heterogeneity / total variability):   32.00%
## H^2 (total variability / sampling variability):  1.47
## 
## Test for Heterogeneity: 
## Q(df = 4) = 5.7272, p-val = 0.2205
## 
## Model Results:
## 
## estimate      se    zval    pval   ci.lb   ci.ub     
##   0.3153  0.0867  3.6376  0.0003  0.1454  0.4852  ***
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Meta-regression output

## [1] "Insufficient studies for meta-regression (either <2 studies or only 1 vaccine type)"

Intervention-specific outputs

Summary of cholera studies

## [1] "Insufficient studies (n<2)"

Summary of rotavirus studies

## 
## Random-Effects Model (k = 5; tau^2 estimator: REML)
## 
##   logLik  deviance       AIC       BIC      AICc  
##   0.8350   -1.6700    2.3300    1.1026   14.3300  
## 
## tau^2 (estimated amount of total heterogeneity): 0.0120 (SE = 0.0265)
## tau (square root of estimated tau^2 value):      0.1094
## I^2 (total heterogeneity / total variability):   32.00%
## H^2 (total variability / sampling variability):  1.47
## 
## Test for Heterogeneity: 
## Q(df = 4) = 5.7272, p-val = 0.2205
## 
## Model Results:
## 
## estimate      se    zval    pval   ci.lb   ci.ub     
##   0.3153  0.0867  3.6376  0.0003  0.1454  0.4852  ***
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Summary of PV3 studies

## [1] "Insufficient studies (n<2)"

Meta-regression: secondary moderators

Age group

## [1] "Residual heterogeneity not significant (p>0.05)"

Income setting

## [1] "Residual heterogeneity not significant (p>0.05)"

Background immunogenicity (seroconversion rate in the control group)

## [1] "Residual heterogeneity not significant (p>0.05)"

OPV-specific analysis

Forest plot

## [1] "Insufficient studies (n<2)"

Funnel plot

## [1] "Insufficient studies (n<2)"

Egger’s test

Infants replicated across vaccines, therefore separate tests performed

## [1] "OPV1:"
## [1] "Insufficient studies (n<3)"
## [1] "OPV2:"
## [1] "Insufficient studies (n<3)"
## [1] "OPV3:"
## [1] "Insufficient studies (n<3)"

Meta-analysis output

## [1] "Insufficient studies (n<2)"

Meta-regression output

## [1] "Insufficient studies for meta-regression (either <2 studies or only 1 vaccine type)"

Serotype-specific outputs

Summary of PV1 studies

## [1] "Insufficient studies (n<2)"

Summary of PV2 studies

## [1] "Insufficient studies (n<2)"

Summary of PV3 studies

## [1] "Insufficient studies (n<2)"